Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials

► Cinnamic acid/4-aminoquinoline hybrids were synthesized as dual-action drugs. ► Hybrids were linked via a retro-enantio dipeptide. Its absence was also evaluated. ► Their power to inhibit hemozoin growth, falcipain and blood-stage Pf were assessed. ► Hybrids with dipeptide were active against blood-stage Pf and hemozoin growth. ► Molecules without spacer were better falcipain-2 inhibitors.