New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain

► New quinoline-5,8-dione and hydroxynaphthoquinone derivatives were synthesized. ► Tested for antiplasmodial activity against Plasmodium falciparum. ► Of the 15 compounds, 7a-c, 8a, 9b, 11, and 15 were effective in growth inhibition with an IC50 value below 5 μM. ► Compound 7a was most active with IC50 2.21 μM.