Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

►New series of quinoline carbohydrazone derivatives were synthesized. ►X-ray crystallographic study of the title compound 5j was carried out. ►In vitro antibacterial and antimycobacterial screening were carried out. ►Compounds 5b, 5e, 5h, 5j and 6c showed substantial antitubercular activity. ►Docking studies were carried out.