Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group

► Tripeptidomimetics as HDACs inhibitors. ► HDACs inhibitors with linear linker and branched cap group. ► More potent HDAC8 inhibitory activity than clinically used drug SAHA. ► Another strategy for designing HDAC8 selective inhibitor.