A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N′-(aminoacid-acyl)-hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis

► β-Tetrahydrocarbolinecarbonyldrazines were aromatized to β-carbolinecarbonyl- hydrazines. ► The aromatization decreased the proximity of the side chain to the carboline-cycle. ► The aromatization increased the in vitro anti-platelet aggregation activity. ► The aromatization increased the in vivo anti-thrombotic activity. ► These could be understood with a 3D QSAR analysis.