Synthesis and antimycobacterial evaluation of 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide analogues

► A series of 18 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamides were synthesized. ► Compound 4c was found to be the most promising compound active against MTB and MDR-TB. ► When compared with INH the compound, 4c was 13.6 folds more active against MDR-TB.