کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7803078 1501176 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antitumor activity of novel pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antitumor activity of novel pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one derivatives
چکیده انگلیسی
► New pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones bearing different substituents at position 3 were synthesized. ► Some of these new compounds exhibited good antitumor activity against MCF7 when compared to doxorubicin as a reference drug. ► The best results was obtained by derivatives bearing thioxo, alkylthio or amino groups at position 3. ► The 3-amino derivative 12 was the most potent compound in this screening with IC50 equal to 3.74 μg/mL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 6, June 2011, Pages 2031-2036
نویسندگان
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