Lipid-like sulfoxides and amine oxides as inhibitors of mast cell activation

► Alkylphospholipids are known to be active in mast cell degranulation assays. ► In silico screening for lipid-like inhibitors of mast cell activation was carried out. ► Analogs of screening hits were synthesized to obtain SAR information. ► Sulfoxide and amine oxide containing lipid-like compounds were identified as new inhibitors.