2,3-Dideoxy hex-2-enopyranosid-4-uloses as promising new anti-tubercular agents: Design, synthesis, biological evaluation and SAR studies

► 2,3-Dideoxy hex-2-enopyranosid-4-uloses as promising new anti-tubercular agents. ► Exhibit in vitro activity against M. tb H37Rv in MIC range of 0.78 μg/mL-25 μg/mL. ► Small and simple molecules which could be easily synthesized from d-glucose. ► 5g having MIC (0.78 μg/mL) and SI (13.5) identified as a promising lead molecule.