N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

► N-acylaminophenothiazines are a new family of multifunctional neuroprotective agents. ► Selective inhibition of BuChE vs. AChE. ► Good CNS penetration by PAMPA-BBB assay. ► Neuroprotection vs. oxidative stress, calcium overload, okadaic acid and beta-amyloid. ► Calcium channel modulating activity.