Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

►In this manuscript, we have synthesized a series of new β-carboline-tripeptide conjugates.►Their anti-inflammatory properties were examined in a mouse model of xylene-induced ear edema.►The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay.►Compound 4a exerts a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.