Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

► 3-Methylene-substituted indolinone scaffold as antimalarials. ► Reaction is highly regioselective leading to the preferred formation of the Z isomer. ► 3-methylene-substituted indolinones as inhibitors of falcipain-2. ► 3-methylene-substituted indolinones displayed antiplasmodial activity in low micromolar range.