A novel artificial superoxide dismutase: Non-covalent conjugation of albumin with a MnIII salophen type complex

► The synthesis of non-covalent conjugates has become an important approach. ► These artificial enzymes are attractive in the understanding of reaction mechanisms. ► The design of synthetic mimics of SOD enzymes is of particular interest. ► The microenvironment of BSA increases the SOD activity of a low-molecular-weight SOD mimetic. ► The strategy of non-covalent binding with proteins is new and promising in the field of SOD mimics.