کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7803284 1645397 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia
چکیده انگلیسی
► We synthesised a limited series of 5-membered spiroheterocycles-benzopyran as new potential tool to study myocardial-ischemia. ► The compounds were evaluated for their cardioprotective activity on cultured H9c2 cardiomyoblasts. ► The evaluation of the activity of the most active compound 1a on rat hearts submitted to ischemia/reperfusion cycles showed that mitoKATP channel is involved in cardioprotection. ► The structural contraction of the lead compound A does not affect the cardioprotective activity, thus indicating that also the spiro-oxazolidinone scaffold represents a valid structural motif to offer cardioprotection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 3, March 2011, Pages 966-973
نویسندگان
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