کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7803284 | 1645397 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
⺠We synthesised a limited series of 5-membered spiroheterocycles-benzopyran as new potential tool to study myocardial-ischemia. ⺠The compounds were evaluated for their cardioprotective activity on cultured H9c2 cardiomyoblasts. ⺠The evaluation of the activity of the most active compound 1a on rat hearts submitted to ischemia/reperfusion cycles showed that mitoKATP channel is involved in cardioprotection. ⺠The structural contraction of the lead compound A does not affect the cardioprotective activity, thus indicating that also the spiro-oxazolidinone scaffold represents a valid structural motif to offer cardioprotection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 3, March 2011, Pages 966-973
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 3, March 2011, Pages 966-973
نویسندگان
Simona Rapposelli, Maria Cristina Breschi, Vincenzo Calderone, Maria Digiacomo, Alma Martelli, Lara Testai, Michael Vanni, Aldo Balsamo,