Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

A series of quinoline derivatives have been designed, synthesized and evaluated in vitro for their cholinesterase inhibitory activity and selectivity and Ca channel antagonist. Docking analysis allowed to identify the binding mode in the active site and to explain the observed selectivities.