Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety

► Novel quinoline and pyrimidoquinoline derivatives with significant anticancer activity. ► For quinoline derivatives, the most potent having benzamide 9. ► For pyrimidoquinoline derivatives, the most potent having 4-bromophenyl 18. ► Compounds may show significant carbonic anhydrase inhibitory activity.