Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

► Novel ketolides were synthesized and evaluated for their antibacterial activity. ► 9n and 9k showed better antibacterial activity than telithromycin. ► 9a, 9e, 9k and 9n have in vitro antibacterial spectrum similar to telithromycin. ► They are potent against erm and mef-gene containing resistant strains.