کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
783505 1465320 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A multiphase model of tumour segregation in situ by a heterogeneous extracellular matrix
ترجمه فارسی عنوان
یک مدل چند فاز از جداسازی تومور در محل توسط یک ماتریس خارج سلولی ناهمگن
کلمات کلیدی
مدل سازی سرطان، ماتریکس غیر سلولی، مدل سازی چند مرحلهای
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی مکانیک
چکیده انگلیسی


• We deduce a multiphase model to describe tumour growth able to deal with cell segregation by thick ECM.
• We relate the transition rule of cells through the ECM to their microscopic characteristics.
• Simulations show the importance of nucleus stiffness and size w.r.t. ECM pore size.

Normal and tumour cells live in a fibrous environment that is often very heterogeneous, even characterized by the presence of basal membranes and regions with high density of collagen fibres that physiologically comparmentalize cells in well defined regions, as for in situ tumours. In case of metastatic tumours these porous structures are instead invaded by cancer cells. The aim of this paper is to propose a multiphase model that is able to describe cell segregation by thick porous structures and to relate the transition rule that determines whether cells will pass or not to microscopic characteristics of the cells, such as the stiffness of their nucleus, their adhesive and traction abilities, the relative dimension of their nucleus with respect to the dimension of the pores of the extra-cellular matrix.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Non-Linear Mechanics - Volume 75, October 2015, Pages 22–30
نویسندگان
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