کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
793613 | 1467126 | 2010 | 13 صفحه PDF | دانلود رایگان |
A rolling model for cell motility is proposed here where the movement of cell is treated as a result of the continuous release and growth of adhesions at the trailing and leading edge of the cell, respectively. The appearance of actin polymerization is key in this model as it breaks the symmetry of adhesion characteristics. The cell speed predicted here is in the correct range and exhibits a biphasic relationship with the cell–substrate adhesive strength which is consistent with experimental observations. We will show that this biphasic dependence of cell speed on adhesivity is due to the interplay between the energy dissipation associated with cell movement and the thermal fluctuations of actin filaments necessary for polymerization. Our results also suggest that the mobility of adhesion molecules is not only unnecessary but may actually limit cell motility.
Journal: Journal of the Mechanics and Physics of Solids - Volume 58, Issue 4, April 2010, Pages 502–514