کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8154104 1524770 2018 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract
ترجمه فارسی عنوان
شبیه سازی عددی از نانو مواد مغناطیسی هدفمند در دستگاه تنفسی پایین تر بیمار
کلمات کلیدی
هیدروموتور مغناطیسی، بیمار خاص نانوذرات، مدل لاگرانژی، مدل یولر، دستگاه تنفسی پایین
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
Magnetic nano drug targeting, with an external magnetic field, can potentially improve the drug absorption in specific locations of the body. However, the effectiveness of the procedure can be reduced due to the limitations of the magnetic field intensity. This work investigates this technique with the Computational Fluid Dynamics (CFD) approach. A single rectangular coil generates the external magnetic field. A patient-specific geometry of the Trachea, with its primary and secondary bronchi, is reconstructed from Digital Imaging and Communications in Medicine (DICOM) formatted images, throughout the Vascular Modelling Tool Kit (VMTK) software. A solver, coupling the Lagrangian dynamics of the magnetic nanoparticles with the Eulerian dynamics of the air, is used to perform the simulations. The resistive pressure, the pulsatile inlet velocity and the rectangular coil magnetic field are the boundary conditions. The dynamics of the injected particles is investigated without and with the magnetic probe. The flow field promotes particles adhesion to the tracheal wall. The particles volumetric flow rate in both cases has been calculated. The magnetic probe is shown to increase the particles flow in the target region, but at a limited extent. This behavior has been attributed to the small particle size and the probe configuration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 451, 1 April 2018, Pages 554-564
نویسندگان
, , ,