کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8155445 1524820 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile synthesis of manganese ferrite/graphene oxide nanocomposites for controlled targeted drug delivery
ترجمه فارسی عنوان
سنتز نانوکامپوزیت های فریت منگنز / اکسید گرافن برای تحویل دارو هدفمند
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
In this study, manganese ferrite/graphene oxide (MnFe2O4/GO) nanocomposites as controlled targeted drug delivery were prepared by a facile sonochemical method. It was found that GO nanosheets were fully exfoliated and decorated with MnFe2O4 nanoparticles having diameters of 5-13 nm. The field-dependent magnetization curve indicated superparamagnetic behavior of the obtained MnFe2O4/GO with saturation magnetization of 34.9 emu/g at room temperature. The in vitro cytotoxicity testing exhibited negligible cytotoxicity of as-prepared MnFe2O4/GO even at the concentration as high as 150 μg/mL. Doxorubicin hydrochloride (DOX) as an anti-tumor model drug was utilized to explore the application potential of MnFe2O4/GO for controlled drug delivery. The drug loading capacity of this nanocarrier was as high as 0.97 mg/mg and the drug release behavior showed a sustained and pH-responsive way.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 401, 1 March 2016, Pages 647-650
نویسندگان
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