کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8157046 1524859 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Numerical simulation of magnetic nanoparticles targeting in a bifurcation vessel
ترجمه فارسی عنوان
شبیه سازی عددی نانوذرات مغناطیسی هدفمند در یک رگ دوگانه
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
Guiding magnetic iron oxide nanoparticles with the help of an external magnetic field to its target is the principle behind the development of super paramagnetic iron oxide nanoparticles (SPIONs) as novel drug delivery vehicles. The present paper is devoted to study on MDT (Magnetic Drug Targeting) technique by particle tracking in the presence of magnetic field in a bifurcation vessel. The blood flow in bifurcation is considered incompressible, unsteady and Newtonian. The flow analysis applies the time dependent, two dimensional, incompressible Navier-Stokes equations for Newtonian fluids. The Lagrangian particle tracking is performed to estimate particle behavior under influence of imposed magnetic field gradients along the bifurcation. According to the results, the magnetic field increased the volume fraction of particle in target region, but in vessels with high Reynolds number, the efficiency of MDT technique is very low. Also the results showed that in the bifurcation vessels with lower angles, wall shear stress is higher and consequently the risk of the vessel wall rupture increases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 362, August 2014, Pages 58-71
نویسندگان
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