کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
816611 1469267 2015 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of antimicrobial, analgesic wound healing and antioxidant activities of some newly synthesized oxychinolin derivatives and their characterization
ترجمه فارسی عنوان
بررسی اثر ضد میکروبی، زخم ضد درد و فعالیت آنتی اکسیدانی برخی از مشتقات اکسین کینولین جدید سنتز شده و خصوصیات آنها
کلمات کلیدی
سولوتوکرومیک، ضد میکروبی ضد درد، آنتی اکسیدان، التیام زخم، اکسین کینولین،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی (عمومی)
چکیده انگلیسی
A series of aryl and heteroaryl substituted oxychinolin derivatives have been synthesized and spectral characterizations have been conducted with different modern analytical techniques. The antimicrobial activities of the novel synthesized oxychinolin analogs against different microbial strains have been screened by agar diffusion method. The compounds 4g and 4h were observed with significant antibacterial activity in comparison to reference antibiotic (ampicillin) against most of the bacterial pathogens. Compounds 4-((8-hydroxyquinolin-5-yl) diazenyl)-N-(5-methyl isoxazol-3-yl) benzene sulfonamide (4c), 4-((8-hydroxyquinolin-5-yl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (4g) and 2-((8-hydroxyquinolin-5-yl)diazenyl) benzoic acid (4h) showed zone of inhibition at MIC level 31.25 µg mL−1 against most of the organisms. The compounds 4g and 4h are observed with significant wound healing, analgesic and potential antioxidant activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Beni-Suef University Journal of Basic and Applied Sciences - Volume 4, Issue 3, September 2015, Pages 232-245
نویسندگان
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