Efficacy of five anthelmintics against a natural Fasciola species infection in cattle

This study aims to evaluate the efficacy of five different anthelmintics against Fasciola species in naturally infected cattle in Beni-Suef, Egypt. In a randomized trial, 55 cattle were divided into 5 treated groups and untreated one. On zero day each group was administered one of the five anthelmintics; albendazole, rafoxanid, oxyclozanide, oxyclozanide and levamizole in combination and triclabendazole. Faecal samples from each animal in the groups were taken on zero day of treatment then on 1, 3, 7, 14, 28, 56 and 84 days post-treatment. The efficacy of the used anthelmintics was decided by fecal egg count reduction percent in which the fecal egg was investigated by sedimentation technique. The results in groups of oxyclozanide, oxyclozanide and levamizole combination and triclabendazole indicated that, these anthelmintics were found of high efficacy against fascioliasis through, 100% reduction in fecal egg count in the day 14 post-treatment. However, the results for albendazole and rafoxanid groups yielded lower efficacy levels, with faecal egg count reductions between 75% and 80.58%, over the period 7–84 days post-treatment. These results are highly indicative for albendazole and rafoxanid resistant Fasciola in cattle in this area of Egypt.