کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
818019 | 1469431 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preparation and characterization of hollow Fe3O4/SiO2@PEG–PLA nanoparticles for drug delivery Preparation and characterization of hollow Fe3O4/SiO2@PEG–PLA nanoparticles for drug delivery](/preview/png/818019.png)
In this study we present a novel targeted anticancer drug delivery, which was size controlled Fe3O4/SiO2 hollow microspheres (HMS) as magnetic core and poly (ethylene glycol)-poly–(d,l-lactide) (PEG–PLA) surface coating (HMS@PEG–PLA). And investigations were to test a new convenient method, which is one-step precipitation polymerization on HMS, forming magnetic hollow polymer microspheres. The HMS@PEG–PLA which have hollow structure and uniform size were characterized by Transmission Electron Microscopy (TEM). Vibrating Sample Magnetometer (VSM) showed a characteristic of super paramagnetic with saturation magnetization value of about 19.78 emu/g. In vitro cytotoxicity of Fe3O4/SiO2@PEG–PLA (HMS@PEG–PLA) hollow microspheres were of low toxicity, so it can be used as a drug carrier, and cisplatin (CDDP) as the model drug release behavior was researched. The results have exhibited preferable release properties.
Journal: Composites Part B: Engineering - Volume 54, November 2013, Pages 194–199