Functionalized magnetic composites based on block copolymers poly(succinimide)-b-poly(ethylene glycol) with potential applications in blood detoxification

Functionalized magnetic composites based on block copolymers poly(succinimide)-b-poly(ethylene glycol) have been obtained by immobilization of biotin on composites particles via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDAC). Dynamic light scattering measurements showed that hydrodynamic mean diameters of the functionalized particles were about 500 nm and indicate their potential to be formulated as injectable suspensions. These particles exhibit a superparamagnetic behavior and good magnetic saturation, characteristics that recommend them for magnetic separation techniques. Blood coagulation assays indicated that functionalized magnetic composites did not induce thrombogenic reactions in contact with blood.