کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8257464 | 1534413 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treatment and clinical outcomes of elderly idiopathic membranous nephropathy: A multicenter cohort study in Korea
ترجمه فارسی عنوان
درمان و نتایج بالینی نفروپاتی غشایی ایدئوپاتیک سالمندان: مطالعه کوهورت چند قلو در کره
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Idiopathic membranous nephropathy (MN) is the most common glomerulonephritis in elderly patients showing nephrotic syndrome. However, little is known about its treatment options and outcomes in elderly MN patients at long term follow-up. We retrospectively enrolled patients with biopsy-proven MN between April 1990 and December 2015 from eight tertiary hospitals in Korea. Among them, we excluded patients who had secondary causes of MN and subnephrotic-range proteinuria. We evaluated the presenting features and clinical outcomes and analyzed the all-cause mortality, renal outcomes, infection, and remission with respect to age. During the median follow-up at 77.2 months, 198 younger patients (<65â¯years) and 133 elderly patients (â¥65 years) were enrolled. Age was an independent risk factor for all-cause mortality, renal outcome, and infection (for all Pâ¯<â¯0.05) except remission. In elderly patients, there was no significant factor associated with mortality rate. The use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) was significantly associated with renal outcome and infection (renal outcome, hazard ration [HR] 0.06, 95% confidence intervals [CI] 0.01-0.36, Pâ¯=â¯0.003; infection, HR 0.20, 95% CI 0.04-0.94, Pâ¯=â¯0.041). Immunosuppressant therapy significantly increased renal outcome (Pâ¯=â¯0.045) and infection (Pâ¯=â¯0.029) compared with conservative therapy. In conclusion, old age is one of the clinically important predictors for MN patients. Among the treatment of elderly MN patients, only ACEI or ARB was associated with beneficial effects on renal outcome and infection. Elderly MN patients need a more tailored regimen considering their comorbidities and condition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 76, MayâJune 2018, Pages 175-181
Journal: Archives of Gerontology and Geriatrics - Volume 76, MayâJune 2018, Pages 175-181
نویسندگان
Eunjin Bae, Sung Woo Lee, Seokwoo Park, Dong Ki Kim, Hajeong Lee, Hyuk Huh, Ho Jun Chin, Shina Lee, Dong-Ryeol Ryu, Ji In Park, Sejoong Kim, Dong Jun Park, Shin-Wook Kang, Yon Su Kim, Yun Kyu Oh, Yong Chul Kim, Chun Soo Lim, Jung Tak Park, Jung Pyo Lee,