کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8257935 1534437 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently?
چکیده انگلیسی
Our study aimed to compare cognitive status and declines in AD with/without small vessel disease (SVD) and SIVD at baseline and 1-year follow-up. Patients with Alzheimer's disease without small vessel disease (AD(−)SVD) (n = 148), Alzheimer's disease with small vessel disease (AD(+)SVD) (n = 94) and SIVD (n = 60) were recruited from database of multiple centers in Korea. Basic demographics and detailed neuropsychological results were compared. AD, regardless of SVD, showed worse memory and better executive function than SIVD at baseline. Mini-Mental State Examination scores and visual memory function declined more in AD than those in SIVD whereas Barthel Activities of Daily Living (B-ADL) scores declined more in SIVD. AD showed different patterns of cognitive impairment compared with SIVD. After 1 year, AD showed more rapid cognitive decline in some domains. Further investigations with longer follow-up duration may be needed to confirm the cumulative effects of SVD in AD and different patterns of decline between AD and SIVD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 58, Issue 3, May–June 2014, Pages 415-419
نویسندگان
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