کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
826129 907904 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Why the radiation-attenuated cercarial immunization studies failed to guide the road for an effective schistosomiasis vaccine: A review
ترجمه فارسی عنوان
چرا مطالعات ایمن سازی سر و گردن از طریق تشخیص سریع نتوانست جاده را برای واکسیناسیون شیستوسومیوز موثر هدایت کند: یک بازبینی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to 90% was achieved, providing a sound proof that vaccination against this infection is feasible. Extensive histopathological, tissue mincing and incubation, autoradiographic tracking, parasitological, and immunological studies led to defining conditions and settings for achieving optimal protection and delineating the resistance underlying mechanisms. The present review aims to summarize these findings and draw the lessons that should have guided the development of an effective schistosomiasis vaccine.

Schistosomula- and adult worms-derived antigens induce predominant Th1 immune responses. The radiation-attenuated cercariae vaccine efficacy is dependent on induction of Th1 and Th2 immune responses. Accordingly, schistosomula- and adult worms-derived antigens used for effective vaccination must be combined with Th2 immune responses-inducing cytokines or molecules as adjuvant.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Advanced Research - Volume 6, Issue 3, May 2015, Pages 255–267
نویسندگان
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