کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
826452 907928 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High performance liquid chromatographic determination of some guaiphenesin-containing cough-cold preparations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
High performance liquid chromatographic determination of some guaiphenesin-containing cough-cold preparations
چکیده انگلیسی

This paper presents different HPLC methods for the simultaneous determination of some guaiphenesin-containing cough-cold preparations. Three pharmaceutically available combinations were analyzed: salbutamol sulfate (SAL) and guaiphenesin (GUA), combination I; ascorbic acid (ASC), paracetamol (PAR) and guaiphenesin (GUA), combination II; and theophylline anhydrous (THE), guaiphenesin (GUA) and ambroxol hydrochloride (AMB), combination III. A 250 × 4.6 mm C-18 column was used for all combinations. The mobile phase for the three combinations consisted of a mixture of methanol and 0.01 M aqueous phosphate buffer solution. The pH of the mobile phase was adjusted to 3.2, 6.2 and 3.8 for combinations I, II and III, respectively. The proposed HPLC methods were successfully applied to the determination of the investigated drugs, both in synthetic mixtures and in pharmaceutical preparations, without any matrix interference and with high precision and accuracy. Different aspects of analytical validation are presented in the text.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Advanced Research - Volume 2, Issue 2, April 2011, Pages 121–130
نویسندگان
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