کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8272751 1535073 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intercepting Parkinson disease non-motor subtypes: A proof-of-principle study in a clinical setting
ترجمه فارسی عنوان
تعویض زیرمجموعه های غیرمتوسی بیماری پارکینسون: یک مطالعه اثبات اصل در یک محیط بالینی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
We have analyzed NMS burden assessed through an extensive clinical and neuropsychological battery in 137 consecutive non-demented PD patients genotyped for MAPT haplotypes (H1/H1 vs H2 carriers) in order to explore the applicability of the “anatomo-clinical”, “motor” or “genetic” models for subtyping PD in a clinical setting; a subsequent independent analysis was conducted to verify a possible cluster distribution of NMS. No clear-cut NMS profiles according to the previously described models emerged: in our population, the autonomic dysfunctions and depressive symptoms represent the leading determinant of NMS clusters, which seems to better fit with the hypothesis of a “neurotransmitter-based” model. Selective preferential neurotransmitter network dysfunctions may account for heterogeneity of PD and could address translational research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 388, 15 May 2018, Pages 186-191
نویسندگان
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