کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8273252 | 1535078 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus
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کلمات کلیدی
NMDARLCNECNMDAR encephalitisCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیEndometrioid carcinoma - کارسینوم آندومتریوئیدLarge cell neuroendocrine carcinoma - کارسینوم عصبی عصبی سلولی بزرگNeuroendocrine carcinoma - کارسینوم عصبی عضلانیN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartate
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A 44-year-old woman presented with a large-cell neuroendocrine carcinoma and uterine endometrioid carcinoma with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Following the diagnosis of uterine cancer, the patient suddenly developed psychosis with abnormal behaviors, delusions, irritability, and forgetfulness. The cerebrospinal fluid tested positive for anti-NMDAR antibodies (encoding the NR1 subunit). The patient was diagnosed with paraneoplastic limbic encephalitis due to uterine cancer. Histology of multiple abdominal metastatic samples revealed a neuroendocrine tumor. Her consciousness improved temporarily after tumor resection and comprehensive immunomodulatory therapy. On day 104 after admission, the patient died of multiple organ failure. The autopsy revealed a perivascular infiltration of inflammatory cells in the amygdala and NMDAR-positive cells in the primary uterine cancer. Our findings demonstrated that neuroendocrine tumors can induce anti-NMDAR encephalitis, which is consistent with three previous reports. A comprehensive treatment with resection of the carcinoma, immunoglobulins, and plasma exchange can induce a partial improvement of the symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 383, 15 December 2017, Pages 72-74
Journal: Journal of the Neurological Sciences - Volume 383, 15 December 2017, Pages 72-74
نویسندگان
Manami Kobayashi, Kenya Nishioka, Masashi Takanashi, Anri Hattori, Yuri Shojima, Arisa Hayashida, Akiko Sumii, Tsuyoshi Ota, Yasuhisa Terao, Kazumasa Yokoyama, Nobutaka Hattori,