Effect of Caesalpinia bonducella seed extract on histoarchitecture of some vital organs and clinical chemistry in female albino rats

The effect of an ethanolic seed extract of Caesalpinia bonducella F., (Caesalpiniaceae) on the histoarchitecture of the some vital organs and clinical chemistry was evaluated in Wistar female albino rats. The study was divided into four groups. Group I received distilled water and served as vehicle treated control. Groups II, III and IV were orally administered 100, 200 and 300 mg/kg b.wt dose of seed extract respectively for 10 consecutive days and subsequently euthanized twenty four hours after the last dose. Histoarchitecture of the vital tissues in treated groups appeared normal. Hematological analysis showed a significant increase in RBC count, various types of WBCs, platelet count, hemoglobin levels and packed cell volume levels in all the seed extract treated groups. Serum biochemistry revealed significantly decreased cholesterol, triglycerides and creatinine levels whereas HDL level was found to be significantly increased in all the treated groups. Our results suggest that the ethanolic seed extract of C. bonducella probably possesses chemical constituents of cytoprotective potential and should be further explored as a source of natural medicine.