کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
827435 | 908002 | 2011 | 8 صفحه PDF | دانلود رایگان |
The reaction of anthrone 1 with 4-aminoantipyrine and thiosemicarbazide afforded 4-(anthracen-9(10H)-ylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 2 and anthracen-9(10H)-one thiosemicarbazone 5, respectively. Oxidation of compound 2 with potassium permanganate gave 4-(anthracen-9(10H)-ylideneamino)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H pyrazole-5-carboxylic acid 3 which on reaction with o-phenylenediamine gave 4-(anthracen-9(10H)-ylideneamino)-5-(1H-benzimidazol-2-yl)-1-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 4. Furthermore, compound 5 was condensed with different substituted phenacyl bromide to give a series of 2-(anthracen-9(10H)-ylidenehydrazono)-5-substituted-2,3-dihydro-1H-thiazole 6a–g. Compound 5 also reacted with chloroacetic acid affording 2-(anthracen-9(10H)-ylidenehydrazono)thiazolidin-4-one 7. The structures of all the products have been determined by elemental analysis and spectral studies. All compounds have been screened for their antibacterial and antifungal studies. The results are summarized in Table 1 and Table 2.
Journal: Journal of King Saud University - Science - Volume 23, Issue 4, October 2011, Pages 399–406