کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8274749 1535102 2016 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retinoids and motor neuron disease: Potential role in amyotrophic lateral sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Retinoids and motor neuron disease: Potential role in amyotrophic lateral sclerosis
چکیده انگلیسی
Several reports in the literature suggest that retinoids are involved in proteostasis regulation, by modulating its two major pathways, the ubiquitin-proteasome system and the autophagy-lysosome response. Additionally, there are some evidences for a role of retinoids themselves, in ALS pathogenesis. In this review, we discuss the importance of proteostasis disruption as a trigger for MN degeneration and the capability of retinoids to modulate it, as well as the potential therapeutic role of retinoids as a new therapy in ALS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 360, 15 January 2016, Pages 115-120
نویسندگان
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