کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8275004 | 1535101 | 2016 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury
ترجمه فارسی عنوان
درمان دستی به عنوان یک درمان مؤثر برای فیبروز در یک مدل موش آسیب بیش از حد اندام فوقانی
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کلمات کلیدی
TGF-β1(TNFα)(ECM)(MS) - (خانم)Overuse injury - آسیب بیش از حدRepetitive strain injury - آسیب فشار تکراریCumulative trauma disorder - اختلال ترومای تجمعیmusculoskeletal disorders - اختلالات اسکلتی عضلانیWork-related musculoskeletal disorders - اختلالات اسکلتی عضلانی مرتبط با کارMobilization - بسیجTransforming Growth Factor Beta - تبدیل بتا فاکتور رشدtumor necrosis factor alpha - تومور نکروز عامل آلفاFibrosis - فیبروز یا فساد الیافExtracellular matrix - ماتریکس خارج سلولیMassage - ماساژmilliseconds - میلی ثانیهCollagen - کلاژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Key clinical features of carpal tunnel syndrome and other types of cumulative trauma disorders of the hand and wrist include pain and functional disabilities. Mechanistic details remain under investigation but may involve tissue inflammation and/or fibrosis. We examined the effectiveness of modeled manual therapy (MMT) as a treatment for sensorimotor behavior declines and increased fibrogenic processes occurring in forearm tissues of rats performing a high repetition high force (HRHF) reaching and grasping task for 12 weeks. Young adult, female rats were examined: food restricted control rats (FRC, n = 12); rats that were trained for 6 weeks before performing the HRHF task for 12 weeks with no treatment (HRHF-CON, n = 11); and HRHF task rats received modeled manual therapy (HRHF-MMT, n = 5) for 5 days/week for the duration of the 12-week of task. Rats receiving the MMT expressed fewer discomfort-related behaviors, and performed progressively better in the HRHF task. Grip strength, while decreased after training, improved following MMT. Fibrotic nerve and connective tissue changes (increased collagen and TGF-β1 deposition) present in 12-week HRHF-CON rats were significantly decreased in 12-week HRHF-MMT rats. These observations support the investigation of manual therapy as a preventative for repetitive motion disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 361, 15 February 2016, Pages 168-180
Journal: Journal of the Neurological Sciences - Volume 361, 15 February 2016, Pages 168-180
نویسندگان
Geoffrey M. Bove, Michele Y. Harris, Huaqing Zhao, Mary F. Barbe,