کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8275102 | 1535103 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study
ترجمه فارسی عنوان
سطح فلزات عصبی در بیماران مبتلا به اسکلروز جانبی آمیوتروپیک: یک مطالعه مورد شاهدی مبتنی بر جمعیت است
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کلمات کلیدی
اسکلروز جانبی جانبی آمیوتروفیک، خون، مو فلزات، بیماری نورون حرکتی، ادرار
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
The association between exposure to toxic metals and amyotrophic lateral sclerosis (ALS) was explored in a population-based case-control study in the Sardinia island (Italy), a region characterized by elevated rates of ALS cases. In 34 patients with ALS (mean age, 62 ± 10 years) and 30 controls (mean age, 65 ± 11 years), Al, Cd, Hg, Mn and Pb were determined in blood, hair and urine by sector field inductively coupled mass spectrometry. Results indicated that, in blood, concentrations of Al (p = 0.045) and Pb were higher (p = 0.026) in ALS patients than in control subjects. In hair, a depletion of Al (p = 0.006) and Mn (p = 0.032) concentrations in ALS subjects respect to controls was found. In urine, no significant differences between cases and controls were observed. Thus, some metals seemed to be associated with ALS degeneration, but a definitive conclusion is still far considering the multiple risk factors (genetic mutations, environmental toxicants and stressors) involved in the disease. Finally, the interpretation that deregulated metal concentrations can be a consequence of the degenerative process, rather than a cause, is also valid.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 359, Issues 1â2, 15 December 2015, Pages 11-17
Journal: Journal of the Neurological Sciences - Volume 359, Issues 1â2, 15 December 2015, Pages 11-17
نویسندگان
Beatrice Bocca, Giovanni Forte, Riccardo Oggiano, Simonetta Clemente, Yolande Asara, Angela Peruzzu, Cristiano Farace, Salvatore Pala, Alessandro Giuseppe Fois, Pietro Pirina, Roberto Madeddu,