Two-year outcome of thymectomy with or without immunosuppressive treatment in nonthymomatous myasthenia gravis and its effect on regulatory T cells

The exact mechanism by which TE ameliorates symptoms of MG is yet not clear. These observations indicate that increased percentages of CD4+CD25+ T cells in MG may be related to disease stability and that TE and synergistic effect with concomitant, continuing immunotherapy augmented the proportion of CD4+CD25+ T cells. On the basis of our observations TE alone is not enough to increase the number of circulating CD4+CD25+ regulatory T cells and to establish complete stable remission.