کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8276460 | 1535113 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lower serum levels of selenium, copper, and zinc are related to neuromotor impairments in children with konzo
ترجمه فارسی عنوان
سطوح پایین سرم سلنیوم، مس و روی با اختلالات عصبی در کودکان مبتلا به کنزو ارتباط دارد
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کلمات کلیدی
سیانید، سلنیوم، فلز مس، فلز روی، کنزو، استرس اکسیداتیو،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We assessed the relationship between key trace elements and neurocognitive and motor impairments observed in konzo, a motor neuron disease associated with cassava cyanogenic exposure in nutritionally challenged African children. Serum concentrations of iron, copper, zinc, selenium, and neurotoxic lead, mercury, manganese, cadmium, and cobalt were measured in 123 konzo children (mean age 8.53 years) and 87 non-konzo children (mean age 9.07 years) using inductively coupled plasma mass spectrometry (ICPMS). Concentrations of trace elements were compared and related to performance scores on the Kaufman Assessment Battery for Children, 2nd edition (KABC-II) for cognition and Bruininks-Oseretsky Test, 2nd edition (BOT-2) for motor proficiency. Children with konzo had low levels of selenium, copper, and zinc relative to controls. Selenium concentration significantly correlated with serum 8,12-iso-iPF2α-VI isoprostane (Spearman r = 0.75, p < 0.01) and BOT-2 scores (r = 0.31, p = 0.00) in children with konzo. Elemental deficiency was not associated with poor cognition. Mean (SD) urinary level of thiocyanate was 388.03 (221.75) μmol/l in non-konzo compared to 518.59 (354.19) μmol/l in konzo children (p < 0.01). Motor deficits associated with konzo may possibly be driven by the combined effects of cyanide toxicity and Se deficiency on prooxidant mechanisms. Strategies to prevent konzo may include dietary supplementation with trace elements, preferentially, those with antioxidant and cyanide-scavenging properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 349, Issues 1â2, 15 February 2015, Pages 149-153
Journal: Journal of the Neurological Sciences - Volume 349, Issues 1â2, 15 February 2015, Pages 149-153
نویسندگان
G.M.-M. Bumoko, N.H. Sadiki, A. Rwatambuga, K.P. Kayembe, D.L. Okitundu, D. Mumba Ngoyi, J.-J.T. Muyembe, J.-P. Banea, M.J. Boivin, D. Tshala-Katumbay,