Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects

MTHFR 677C > T genotype, especially in case of no folate supplementation and GDM, promotes NTD occurrence. MTHM 501A > G only in case of GDM, and BHMT 716G > A only in case of no folate supplementation contribute to the etiology of NTDs.