کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
827845 1470277 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescent amphiphilic copolymer-based tumor theranostics for facile DOX-loading and tumor microenvironment-triggered release
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
Fluorescent amphiphilic copolymer-based tumor theranostics for facile DOX-loading and tumor microenvironment-triggered release
چکیده انگلیسی


• Fluorescent amphiphilic copolymer was designed for tumor theranostic.
• Its pH-sensitive fluorescent intensity can be used for real-time imaging during chemotherapy.
• DOX-loaded micelles were obtained by facile micellization in water.
• They exhibited the tumor microenvironment-responsive controlled release.

Novel reduction/pH dual-stimuli responsive fluorescent amphiphilic copolymer PEG-Cys-P(DEAEMA-co-Rh6GEAm) with detachable poly(ethylene glycol) (PEG) corona through bio-reducible disulfide linkage and pendent cationic groups was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization for tumor theranostic application. The doxorubicin (DOX)-loaded micelles could be easily fabricated via facile micellization in the presence of DOX in water, with a high drug-loading capacity (DLC) of 39.2%. They exhibited fast release ratio with the synergetic effect of reductive agent and pH in the simulated tumor micro-environment, while the leakage can be efficiently avoided in the physiological media. Furthermore, the fluorescence intensity of the copolymer possessed a reversibly transformation in different pH media, indicating the potential application for intracellular fluorescence imaging of tumors.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials & Design - Volume 105, 5 September 2016, Pages 333–340
نویسندگان
, , , , , ,