کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8281796 | 1535147 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy - A case report
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy - A case report Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy - A case report](/preview/png/8281796.png)
چکیده انگلیسی
Hypoglycemia is a well recognized cause of acute symptomatic seizures. The fact that hypoglycemia can cause peripheral neuropathy is less appreciated. We describe a case of insulinoma associated peripheral neuropathy. A 17 year-old previously healthy man was referred for investigation of refractory epilepsy. A history of recurrent seizures, slowly progressive weakness of his feet and hands, and weight gain was obtained. Physical examination showed signs of a chronic sensory-motor polyneuropathy. He was diagnosed with insulinoma and primary hyperparathyroidism, characterizing multiple endocrine neoplasia, type 1 syndrome. Cases of insulinoma associated peripheral neuropathy are very rare. The more characteristic clinical picture appears to be distal weakness, worse in the intrinsic hand and feet muscles, and no or mild sensory signs. Peripheral nervous system symptoms may not completely resolve, despite removal of the cause of hyperinsulinism/hypoglycemia and full reversion of central nervous system symptoms. Mechanisms underlying hypoglycemic neuropathy are still poorly understood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 315, Issues 1â2, 15 April 2012, Pages 172-175
Journal: Journal of the Neurological Sciences - Volume 315, Issues 1â2, 15 April 2012, Pages 172-175
نویسندگان
Anderson Rodrigues Brandão de Paiva, Luiz Henrique Martins Castro, Waldyr Jr., Valmir Passarelli, Carmen Lisa Jorge, Mario Wilson I. Brotto, Maria Teresa Alves Hirata, Paulo EurÃpedes Marchiori,