کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8281961 | 1535151 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D-gene interactions in multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30Â years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 311, Issues 1â2, 15 December 2011, Pages 32-36
Journal: Journal of the Neurological Sciences - Volume 311, Issues 1â2, 15 December 2011, Pages 32-36
نویسندگان
Antonio J. Berlanga-Taylor, Giulio Disanto, George C. Ebers, Sreeram V. Ramagopalan,