کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8318050 | 1538963 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isolated adult turtle brainstems exhibit central hypoxic chemosensitivity
ترجمه فارسی عنوان
گونه های دریچه های جدا شده بالغ لاک پشت دارای حساسیت شیمیایی مرکزی هیپوکی هستند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
During hypoxia, red-eared slider turtles increase ventilation and decrease episodic breathing, but whether these responses are due to central mechanisms is not known. To test this question, isolated adult turtle brainstems were exposed to 240â¯min of hypoxic solution (bath PO2â¯=â¯32.6â¯Â±â¯1.2â¯mmHg) and spontaneous respiratory-related motor bursts (respiratory event) were recorded on hypoglossal nerve roots. During hypoxia, burst frequency increased during the first 15â¯min, and then decreased during the remaining 35-240â¯min of hypoxia. Burst amplitude was maintained for 120â¯min, but then decreased during the last 120â¯min. The number of bursts/respiratory event decreased within 30â¯min and remained decreased. Pretreatment with either prazosin (α1-adrenergic antagonist) or MDL7222 (5-HT3 antagonist) blocked the hypoxia-induced short-term increase and the longer duration decrease in burst frequency. MDL7222, but not prazosin, blocked the hypoxia-induced decrease in bursts/respiratory event. Thus, during bath hypoxia, isolated turtle brainstems continued to produce respiratory motor output, but the frequency and pattern were altered in a manner that required endogenous α1-adrenergic and serotonin 5-HT3 receptor activation. This is the first example of isolated reptile brainstems exhibiting central hypoxic chemosensitivity similar to other vertebrate species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 225, November 2018, Pages 65-73
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 225, November 2018, Pages 65-73
نویسندگان
Michelle E. Bartman, Stephen M. Johnson,