کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8347282 | 1541674 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in mice via vestibular inputs
ترجمه فارسی عنوان
تأثیر هیپرگرویتی بر بیان ژن نوروپپتید های مرتبط با تغذیه هیپوتالامم در موش ها با استفاده از ورودی های ویستیبولار
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CRHAgRPCARTCRH-R1ACTHCRH-R2cocaine- and amphetamine-regulated transcript - دستورالعمل تنظیم شده کوکائین و آمفتامینArc - قوسarcuate nucleus - هسته قوسadrenocorticotropic hormone - هورمون adrenocorticotropiccorticotrophin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینAgouti-related protein - پروتئین مرتبط با Agouti
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham but not in VL mice after 3â¯days of exposure to a 2â¯g environment compared with a 1â¯g environment. Significant decreases in pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript and significant increases in neuropeptide Y, agouti-related protein in the arcuate nucleus and orexin in the lateral hypothalamic area were observed in both Sham and VL mice. After 2 weeks of exposure, CRH and POMC were increased significantly in Sham but not in VL mice. After 8 weeks of exposure, the hypothalamic feeding-related neuropeptides were comparable between Sham and VL mice. These results suggest that the hypothalamic feeding-related neuropeptides may be affected during the exposed duration of hypergravity via vestibular inputs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 105, July 2018, Pages 14-20
Journal: Peptides - Volume 105, July 2018, Pages 14-20
نویسندگان
Satomi Sonoda, Mitsuhiro Yoshimura, Chikara Abe, Hironobu Morita, Hiromichi Ueno, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Hirofumi Hashimoto, Yoshiya Tanaka, Yoichi Ueta,