Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus

- CyO2 and KB2 showed in vitro antibacterial activity against S. aureus.
- CyO2 and KB2 showed none cytotoxic activity against RAW 264.7 at evaluated concentrations.
- CyO2 increased the neutrophil phagocytosis of S. aureus.
- Cyclotides presented in vivo antibacterial activity.