کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348629 | 1541733 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect](/preview/png/8348629.png)
چکیده انگلیسی
LL37, an antimicrobial peptide, exhibits multiple bio-functions in various types of cells, including migration, cytokine production, apoptosis, and angiogenesis. Neovascularization and the subsequent recruitment of stem cells are essential for tissue engineering therapy, including bone regeneration. We hypothesized that LL37 can facilitate successful bone regeneration. To prove this hypothesis, the present study tested the effects of LL37 on bone formation in a rat calvarial bone defect model. Synthesized LL37 markedly induced newly formed bone. Interestingly, morphologically fibroblastic cells were observed in animals treated with LL37 on day 7, the early stage of tissue regeneration, which were positive for STRO-1, a marker of mesenchymal stem cells (MSCs), and accumulated in the bone defect area where cells positive for CD34, a marker of endothelial cells, were also localized. In addition, LL37 stimulated tube formation by endothelial cells and the proliferation of MSCs in vitro. These findings demonstrated for the first time that LL37 can regulate angiogenesis and the recruitment of stem cells to promote bone regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 46, August 2013, Pages 136-142
Journal: Peptides - Volume 46, August 2013, Pages 136-142
نویسندگان
Mizuho Kittaka, Hideki Shiba, Mikihito Kajiya, Takako Fujita, Tomoyuki Iwata, Khung Rathvisal, Kazuhisa Ouhara, Katsuhiro Takeda, Tsuyoshi Fujita, Hitoshi Komatsuzawa, Hidemi Kurihara,