Exercise reduces angiotensin II responses in rat femoral veins

► Angiotensin II responses are discrete in femoral veins. ► Discrete angiotensin II responses in femoral veins may assure the venous return. ► Angiotensin II responses in femoral veins are modulated by nitric oxide. ► Exercise mobilizes prostanoids to blunt the angiotensin II responses in femoral veins. ► Exercise mobilizes endothelin-1 to modulate angiotensin II responses in femoral veins.