Glucagon-like peptides 1 and 2 in health and disease: A review

► GLP-1, GLP-2 and glucagon share a common precursor but have divergent functions. ► A complex inter-dependent relationship exists between GLP-1 secretion, postprandial glycemia and gastric emptying. ► GLP-1 agonists retard gastric emptying. ► GLP-1 could be exploited therapeutically for its extra-intestinal effects. ► GLP-2 shows promise as an intestinotropic agent.