Evidence that kinin B2 receptor expression is upregulated by endothelial overexpression of B1 receptors

► Rat overexpressing the B1R specifically in the vascular endothelium were assessed. ► The BK-induced relaxations were significantly increased in the transgenic rats. ► The expression level of the B2R in the transgenic rats was highly increased. ► The ACE activity and mRNA ACE expression was not altered. ► We report that the B2R expression is upregulated by the overexpression of B1R.